JRM
Journal of Radiology in Medicine

Journal of Radiology in Medicine is an international journal that published original research and articles in all areas of radiology. Its publishes original research articles, review articles, case reports, editorial commentaries, letters to the editor, educational articles, and conference/meeting announcements.

eISSN: 3023-6487
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Original Article
Contribution of automated hippocampal volume measurements to radiological diagnosis in cases of mesial temporal sclerosis
Abstract
Aims: Epilepsy, particularly drug-resistant epilepsy in adults, is often caused by Mesial Temporal Sclerosis (MTS), which can develop after brain injury from febrile illnesses or trauma. Magnetic Resonance Imaging (MRI) is crucial for diagnosing MTS, although challenges such as patient movement and mild or bilateral hippocampal atrophy can complicate the diagnosis. T1-weighted hippocampal volume measurements are effective in detecting MTS, with recent software advancements enabling automatic hippocampal segmentation. This study compared the hippocampal volumes and indices between adults with MTS and a control group of similar age and sex in the Turkish population. This study aimed to highlight structural differences in the hippocampus associated with MTS.
Methods: This study involved a retrospective review of cranial MRIs scans from patients with MTS, confirmed through histopathological examination after epilepsy surgery. To ensure unbiased comparisons, a control group was selected using propensity score matching by age and gender. Two experienced neuroradiologists independently assessed the MRIs findings for MTS without knowledge of hippocampal volumetric data. Hippocampal volumes were measured using FreeSurfer software and standardized using the hippocampal volume index (HVI) and hippocampal asymmetry index (HAI).
Results: In our study of 38 patients, MTS was found in 55.2% of patients on the right side and in 44.8% of patients on the left side, with no bilateral cases. Visual MRI analysis identified MTS in 84.2% of patients, with an area under of curve (AUC) of 0.921. Automatic volumetry detected MTS in 23 patients with an AUC of 0.791. Combining both methods, MTS was diagnosed in 33 patients, with an AUC of 0.922.
Conclusion: Automated volumetric analyses have been shown to enhance the detection of hippocampal volume loss in patients with MTS.

Keywords : Mesial temporal sclerosis, hypocampus volume, automated segmentation

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Article available in :
Volume 1, Issue 4, 2024
Page : 58-64
https://doi.org/10.51271/JRM-0016
Article Information
Received : 04 Eyl 2024
Accepted : 08 Eki 2024
Published : 30 Eki 2024
Corresponding Author :

Kerime Hatun Acar: Department of Radiology, Cerrahpaşa Faculty of Medicine, İstanbul University-Cerrahpasa, İstanbul, Turkiye

[email protected]
Citation : Acar KH, Sarıahmetoğlu ÖF, Arslan S, et al. Contribution of automated hippocampal volume measurements to radiological diagnosis in cases of mesial temporal sclerosis. J Radiol Med. 2024;1(4):58-64.

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